Meet Don Tillman, a socially awkward genetics professor whose life is a testament to the belief that love cannot be reduced to a science. Unlucky in love, Don embarks on the Wife Project - a methodical plan founded on a comprehensive survey designed to find him a life companion. However, his well-arranged life takes a chaotic turn when he crosses paths with Rosie Jarman - the spirited 'world's most incompatible woman.' While assisting Rosie in her search for her biological father through the Father Project, Don discovers that romance does not bow to algorithms. Instead, love has its own unpredictable agenda, toppling Don's rigid perceptions and opening his heart to life's uncalculated joy.