Claudia Kincaid yearns for a change, to feel different, and to teach her parents a lesson in appreciation. With these wishes, she decides to run away to the most unorthodox of sanctuaries—the Metropolitan Museum of Art in New York City. Taking her frugal brother Jamie as an accomplice, they make the museum their new home. However, the thrill of the escape fades, leaving Claudia unsatisfied and yearning for more. It is then that they stumble upon a mysterious statue that could potentially be an undiscovered work of Michelangelo, leading them on a pursuit for its origins. This quest brings them to the previous owner, Mrs. Basil E. Frankweiler, through whom Claudia may just find what she’s been searching for. With ingenuity and spirit, 'From the Mixed-Up Files of Mrs. Basil E. Frankweiler' takes us on a journey of self-discovery, family, and the value of art, wrapped in the excitement of a New York adventure.