Set against the backdrop of 1850s America, 'The Last Runaway' unfolds the journey of Honor Bright, a young English Quaker who emigrates to Ohio. Overwhelmed by sickness and personal loss upon her arrival, Honor finds herself in an unsettling new world scarred by slavery. As she struggles with the harsh realities and the conflict between moral principles and societal norms, Honor becomes entangled in the secretive workings of the Underground Railroad. Friendship and defiance ignite her courage, forcing Honor to confront the cost of standing up for her convictions amidst the fight for freedom.