Inside the enigmatic Area X, a region cut off from civilization, an all-female twelfth expedition embarks on a mission shrouded in mystery and fraught with danger. Led by a biologist narrator, the team's assignment to map the terrain and collect samples spirals into a harrowing journey beyond the realms of their scientific understanding. The expedition members, each guarding their own secrets, must confront the extraordinary life forms and topographical anomalies of Area X as well as the psychological horrors they carry within themselves. With each passing day, the very fabric of reality begins to distort, challenging their sanity and equilibrium, as Annihilation weaves an unnerving tale of discovery, transformation, and the unknown.