In "The Book of Lost Friends," a historical drama unfolds across two timelines. In 1875, during the uneasy era of Reconstruction in Louisiana, three women bound by circumstance embark on a treacherous search for family and inheritance. Hannie, a freed slave, holds onto the hope of reuniting with her long-lost family. Lavinia, the heir of a now desolate plantation, and Juneau Jane, her Creole half-sister, each carry their own secrets and burdens on this journey to Texas. Over a century later, in 1987, Benedetta Silva, a first-year teacher in rural Augustine, Louisiana, uncovers the intertwined history of these women. Amid the struggles of her impoverished students, she discovers a concealed book that holds the potential to alter their understanding of heritage and identity.